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1) NAC Tx Decision & Dosing:

Dosing:

PO

Loading dose is 140 mg/kg PO, then 17 more doses every 4 hours of 70 mg/kg PO. If patient vomits within 1 hour of dose, it must be repeated.

IV

Patients ≥41 kg:

  • Loading Dose: 150 mg/kg in 200 mL of diluent administered over 60 minutes.
  • Dose 2: 50 mg/kg in 500 mL of diluent administered over 4 hours.
  • Dose 3: 100 mg/kg in 1000 mL of diluent administered over 16 hours.

Patients 21 - 40 kg

  • Loading Dose: 150 mg/kg in 100 mL of diluent administered over 60 minutes.
  • Dose 2: 50 mg/kg in 250 mL of diluent administered over 4 hours.
  • Dose 3: 100 mg/kg in 500 mL of diluent administered over 16 hours.

Patients 5-20 kg:

  • Loading Dose: 150 mg/kg in 3 mL/kg of body weight of diluent administered over 60 minutes.
  • Dose 2: 50 mg/kg in 7 mL/kg of body weight of diluent administered over 4 hours.
  • Dose 3: 100 mg/kg in 14 mL/kg of body weight of diluent administered over 16 hours.